CPT/HCPCS
80195
Order Code
CH180
Turnaround Time
24-48 hours
Test Includes
Sirolimus
Specimen Requirements
Specimen Source
Whole blood
Transport Container
(Specimen Container)
(Specimen Container)
EDTA (lavender-top) tube
Preferred Specimens
2 mL whole blood
Minimum Volume (uL)
1 mL
Collection Instructions
(Transport Temperature)
(Transport Temperature)
Transport at Room Temperature
Specimen Stability
| Temperature | Period |
|---|---|
| Room temperature | 5 days |
| Refrigerated | 7 days |
| Frozen | 30 days |
Reject Criteria
Clotted specimen
Special Instructions
Patient Preparation: Collect specimen 1 hour prior to next dose (12 hour trough). Transport Room temperature.
Test Details
Methodology
Chromatography/Mass Spectrometry
Clinical Significance
Sirolimus, LC/MS/MS – Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.
Reference Ranges
3.0 – 18.0 ng/mL
