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Order Code CH180
Turnaround Time 24-48 hours
Test Includes


Specimen Requirements
Specimen Source
Whole blood
Transport Container
(Specimen Container)

EDTA (lavender-top) tube

Preferred Specimens
2 mL whole blood
Minimum Volume (uL)
1 mL
Collection Instructions
(Transport Temperature)
Transport at Room Temperature
Specimen Stability
Temperature Period
Room temperature 5 days
Refrigerated 7 days
Frozen 30 days
Reject Criteria

Clotted specimen

Special Instructions

Patient Preparation: Collect specimen 1 hour prior to next dose (12 hour trough). Transport Room temperature.

Test Details
Chromatography/Mass Spectrometry
Clinical Significance

Sirolimus, LC/MS/MS – Sirolimus is an immunosuppressant drug used to prevent organ graft rejection. Therapeutic drug monitoring is used to optimize dose and avoid toxicity. Peak concentrations are reached in 2 hours following oral administration. Elimination half-life in males is approximately 72 hours; in females approximately 61 hours.

Reference Ranges

3.0 – 18.0 ng/mL