CPT/HCPCS
83921
Order Code
CH374
Turnaround Time
24-48 hours
Test Includes
Methylmalonic acid
Specimen Requirements
Specimen Source
Serum
Transport Container
(Specimen Container)
(Specimen Container)
Serum separator tube (SST); Serum collected in: Royal blue-top tube • Plasma collected in: Sodium heparin (green-top) or sodium heparin (royal blue-top) tube
Preferred Specimens
Serum
Minimum Volume (uL)
1 mL
Collection Instructions
(Transport Temperature)
(Transport Temperature)
Transport at Room Temperature
Specimen Stability
| Temperature | Period |
|---|---|
| Room temperature | 4 days |
| Refrigerated | 7 days |
| Frozen | 10 months |
Test Details
Methodology
Mass Spectrometry
Clinical Significance
The Methylmalonic Acid (MMA) test is used in the diagnosis of acquired cobalamin (vitamin B12) deficiency in adults and to screen for inherited organic acidemia in neonates and infants. Elevated MMA in either blood or urine indicates vitamin B12 deficiency in adults, with MMA acting as a functional biomarker for vitamin B12 status. In neonates and infants, elevated MMA is associated with inborn errors of metabolism [1].
Reference Ranges
87 – 318 nmol/L
Alternative Names
MMA
