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Methylmalonic Acid, Serum

Order Code CH374
Turnaround Time 24-48 hours
Test Includes

Methylmalonic acid

Specimen Requirements
Specimen Source
Transport Container
(Specimen Container)

Serum separator tube (SST); Serum collected in: Royal blue-top tube • Plasma collected in: Sodium heparin (green-top) or sodium heparin (royal blue-top) tube

Preferred Specimens
Minimum Volume (uL)
1 mL
Collection Instructions
(Transport Temperature)
Transport at Room Temperature
Specimen Stability
Temperature Period
Room temperature 4 days
Refrigerated 7 days
Frozen 10 months
Test Details
Mass Spectrometry
Clinical Significance

The Methylmalonic Acid (MMA) test is used in the diagnosis of acquired cobalamin (vitamin B12) deficiency in adults and to screen for inherited organic acidemia in neonates and infants. Elevated MMA in either blood or urine indicates vitamin B12 deficiency in adults, with MMA acting as a functional biomarker for vitamin B12 status. In neonates and infants, elevated MMA is associated with inborn errors of metabolism [1].

Reference Ranges

87 – 318 nmol/L

Alternative Names