CPT/HCPCS
81374
Order Code
CH489
Turnaround Time
24-48 hours
Test Includes
HLA-B27
Specimen Requirements
Specimen Source
Whole blood
Transport Container
(Specimen Container)
(Specimen Container)
EDTA (lavender-top) tube
Preferred Specimens
Whole Blood
Collection Instructions
(Transport Temperature)
(Transport Temperature)
Transport at Room Temperature
Specimen Stability
| Temperature | Period |
|---|---|
| Room temperature | 7 days |
| Refrigerated | 5 days |
| Frozen | Unacceptable |
Reject Criteria
Hemolysis
Lithium heparin (green-top) tube
Clotted
Received frozen
Test Details
Methodology
Polymerase Chain Reaction
Clinical Significance
HLA-B27 is found in 90% of patients with ankylosing spondylitis and 80% in Reiter’s disease. Ankylosing spondylitis affects 1 in 1000 caucasians. Ankylosing spondylitis is 10 times more common among individuals with HLA-B27 compared to individuals without this antigen.
Reference Ranges
Negative
Alternative Names
HLA-B27 Antigen
