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HLA-B27

CPT/HCPCS 81374
Order Code CH489
Turnaround Time 24-48 hours
Test Includes

HLA-B27

Specimen Requirements
Specimen Source
Whole blood
Transport Container
(Specimen Container)

EDTA (lavender-top) tube

Preferred Specimens
Whole Blood
Collection Instructions
(Transport Temperature)
Transport at Room Temperature
Specimen Stability
Temperature Period
Room temperature 7 days
Refrigerated 5 days
Frozen Unacceptable
Reject Criteria

Hemolysis
Lithium heparin (green-top) tube
Clotted
Received frozen

Test Details
Methodology
Polymerase Chain Reaction
Clinical Significance

HLA-B27 is found in 90% of patients with ankylosing spondylitis and 80% in Reiter’s disease. Ankylosing spondylitis affects 1 in 1000 caucasians. Ankylosing spondylitis is 10 times more common among individuals with HLA-B27 compared to individuals without this antigen.

Reference Ranges

Negative

Alternative Names
HLA-B27 Antigen