CPT/HCPCS
86341
Order Code
CH470
Turnaround Time
48-72 hrs
Specimen Requirements
Specimen Source
Serum
Transport Container
(Specimen Container)
(Specimen Container)
Transport Tube
Preferred Specimens
1 mL Serum
Minimum Volume (uL)
0.5 mL
Collection Instructions
(Transport Temperature)
(Transport Temperature)
Room Temperature
Specimen Stability
| Temperature | Period |
|---|---|
| Room temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |
Reject Criteria
Gross hemolysis, Grossly lipemic
Test Details
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Clinical Significance
Glutamic Acid Decarboxylase-65 Antibody – Glutamic acid decarboxylase (GAD-65) antibody is useful to diagnose insulin dependent diabetes mellitus [Type I diabetes (autoimmune-mediated diabetes)] to assess risk for development of Type I diabetes, to predict onset of Type I diabetes, and risk of development of related endocrine disorders, e.g., thyroiditis. Before clinical onset, Type I diabetes is characterized by lymphocytic infiltration of the islet cells, and by circulating autoantibodies against a variety of islet cell antigens, including GAD-65, IA-2 (a tyrosine phosphatase-like protein), and insulin (IAA).
Reference Ranges
<5 IU/mL
