CPT/HCPCS
80159
Order Code
CH495
Turnaround Time
24-48 hours
Test Includes
Clozapine and Norclozapine
Specimen Requirements
Specimen Source
Serum/Plasma
Transport Container
(Specimen Container)
(Specimen Container)
Red-top tube (no gel) Alternative Specimen(s):
Plasma collected in EDTA (lavender top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube
Preferred Specimens
Serum
Minimum Volume (uL)
1 mL
Collection Instructions
(Transport Temperature)
(Transport Temperature)
Refrigerated
Specimen Stability
| Temperature | Period |
|---|---|
| Room temperature | 24 hours |
| Refrigerated | 5 days |
| Frozen | 30 days |
Reject Criteria
Gross hemolysis • Gel barrier/
Serum separator tube (SST)_x000D_
Test Details
Methodology
Liquid Chromatography/Tandem Mass
Spectrometry (LC/MS/MS)_x000D_
Clinical Significance
Clozapine:
Clozapine is an atypical antipsychotic agent. Norclozapine has minimal therapeutic activity
Reference Ranges
Norclozapine 25-400 mcg/L Clozapine
The therapeutic response begins to appear at 100 mcg/L
Refractory schizophrenia appears to require a therapeutic concentration of at least 350 mcg/L (trough, at steady state).
Toxic range: >900 mcg/L
