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Thyroglobulin Quant.

Order Code CH309
Turnaround Time 48 hours
Test Includes

Quantitative Thyroglobulin

Specimen Requirements
Specimen Source
Transport Container
(Specimen Container)

Serum Separator Tube (SST)

Preferred Specimens
Minimum Volume (uL)
0.5 mL
Collection Instructions
(Transport Temperature)
Transport Refrigerated (cold packs)
Specimen Stability
Temperature Period
Room temperature Unacceptable
Refrigerated 72 hours
Frozen 30 days
Reject Criteria

Gross hemolysis, Gross lipemia

Special Instructions

Separate serum from cells within 45 minutes of venipuncture

Test Details
Immunoassay (IA)
Clinical Significance

Thyroglobulin (TG) is a secretory product only of the thyroid gland. The major clinical use of serum TG measurement is to monitor, but not to diagnose, patients with well-differentiated thyroid cancers. The measurement of thyroglobulin, after thyroidectomy and ablation of the thyroid gland, is useful to determine metastasis. Deficient TG synthesis is observed in infants with goitrous hypothyroidism. With immunometric assays (sandwich assays), TGAB interference typically produces inappropriately low TG results, most likely caused by endogenous TG immune complexes that block one or more of the reagent Ab from binding endogenous TG.

Reference Ranges

0.5-55 ng/mL Reference interval does not apply following thyroidectomy when levels should be <0.5 ng/mL or repeatedly low. The presence of antithyroid antibodies may cause decreased levels of measurable thyroglobulin due to competitive inhibition in this immunometric assay.

Alternative Names