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Order Code CH281
Turnaround Time 24 hours
Specimen Requirements
Specimen Source
Transport Container
(Specimen Container)

SST (Tiger Top)

Preferred Specimens
Collection Instructions
(Transport Temperature)
Transport Refrigerated (cold packs)
Specimen Stability
Temperature Period
Room temperature 72 hours
Refrigerated 6 days
Frozen 30 days
Reject Criteria

Citrate plasma specimen; grossly hemolyzed samples

Special Instructions

Separate serum from cells within 45 minutes of venipuncture.

Test Details
Immunoassay (IA)
Clinical Significance

B-type natriuretic peptide (brain natriuretic peptide: BNP) is a small, ringed peptide secreted by the heart to regulate blood pressure and fluid balance.(1) This peptide is stored in and secreted predominantly from membrane granules in the heart ventricles in a pro form (proBNP). Once released from the heart in response to ventricle volume expansion or pressure overload, the N-terminal (NT) piece of 76 amino acids (NT-proBNP) is rapidly cleaved by the enzymes corin and furin to release the active 32-amino acid peptide (BNP). Both BNP and NT-proBNP are markers of atrial and ventricular distension due to increased intracardiac pressure. The New York Heart Association (NYHA) developed a 4-stage functional classification system for congestive heart failure (CHF) based on the severity of the symptoms. Studies have demonstrated that the measured concentrations of circulating BNP and NT-proBNP increase with the severity of CHF based on the NYHA classification.

Reference Ranges

See Laboratory Report