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Methylmalonic Acid, Urine

CPT/HCPCS 82570, 83921
Order Code CH496
Turnaround Time 7 days
Test Includes


Specimen Requirements
Specimen Source
24-hour urine • Random clean-catch urine • Catheterized urine • First void clean-catch_x000D_
Transport Container
(Specimen Container)

Plastic urine container

Preferred Specimens
1.7 mL urine - no preservative
Minimum Volume (uL)
0.6 mL
Collection Instructions
(Transport Temperature)
Transport Refrigerated (cold packs)
Specimen Stability
Temperature Period
Room temperature 4 days
Refrigerated 12 days
Frozen 30 days
Reject Criteria

Received room temperature
Acidified urine

Test Details
Gas Chromatography/Tandem Mass Spectrometry (GC/MS/MS)
Clinical Significance

Methylmalonic Acid, GC/MS/MS, Urine – Methylmalonic Acid (MMA) is useful to diagnose and monitor Vitamin B12 (cobalamin) deficiency, and to diagnose and monitor patients with methylmalonic acidemia.

Reference Ranges

Methylmalonic Acid, Urine 0.3-2.2 mmol/mol creat Creatinine, Random Urine:
0.18-2.48 mmol/L (0-6 Months)
0.18-2.74 mmol/L (7-11 Months)
0.18-9.72 mmol/L (1-2 Years)
0.18-11.49 mmol/L (3-8 Years)
0.18-14.14 mmol/L (9-12 Years)
1.77-23.31 mmol/L (>12 Years)