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Islet Cell Ab Screen w/ Reflex to Titer

Order Code CH465
Turnaround Time
Test Includes

If Islet Cell Antibody Screen is positive, then Islet Cell Antibody Titer will be performed at an additional charge (CPT code(s): 86341).
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Specimen Requirements
Specimen Source
Transport Container
(Specimen Container)

Transport Tube

Preferred Specimens
2 mL Serum
Minimum Volume (uL)
0.5 mL
Collection Instructions
(Transport Temperature)
Refrigerated (cold packs)
Specimen Stability
Temperature Period
Room temperature 48 hours
Refrigerated 14 days
Frozen 6 months
Reject Criteria

Gross hemolysis, Grossly lipemic, Grossly icteric

Special Instructions

Fasting specimen in preferred

Test Details
Immunofluorescence Assay (IFA)
Clinical Significance

Islet Cell Antibody Screen with Reflex to Titer – Type 1 diabetes is characterized by lymphocytic cell infiltrate of the pancreatic islets. Measurement of GAD-65, ICA-512, and Insulin Antibody is a highly sensitive means to assess risk and predict onset of Type 1 diabetes. There is a correlation between the number of positive antibodies and the antibody titers versus the severity of the autoimmune process.

Reference Ranges

Islet Cell Antibody Screen Negative
Islet Cell Antibody Titer <1.25 JDF units