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Direct LDL

Order Code CH137
Turnaround Time 24 hours
Test Includes

Direct LDL

Specimen Requirements
Specimen Source
Serum, Plasma
Transport Container
(Specimen Container)

SST (Tiger Top)/ Lithium Heparin/ Sodium Heparin/ EDTA

Preferred Specimens
Minimum Volume (uL)
2 uL
Collection Instructions
(Transport Temperature)
Transport Refrigerated (cold packs)
Specimen Stability
Temperature Period
Room temperature Unacceptable
Refrigerated 5 days
Frozen 3 months (-80°C)
Test Details
Measured, Liquid Selective Detergent
Clinical Significance

Plasma lipoproteins are spherical particles containing varying amounts of cholesterol, triglycerides, phospholipids, and proteins. The phospholipid, free cholesterol, and protein constitute the outer surface of the lipoprotein particle, while the inner core contains mostly esterified cholesterol and triglycerides. These particles serve to solubilize and transport cholesterol and triglycerides in the bloodstream.

The relative proportions of protein and lipid determine the density of these lipoproteins and provide a basis on which to begin their classification. These classes are: chylomicrons, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL). Numerous clinical studies have shown that the different lipoprotein classes have very distinct and varied effects on coronary heart disease (CHD) risk.

The studies all point to LDL cholesterol as the key factor in the pathogenesis of atherosclerosis and CHD, while HDL cholesterol has been observed to have a protective effect. Even within the normal range of total cholesterol concentrations, an increase in LDL cholesterol can occur with an associated increased risk for CHD.

Reference Ranges

<100 mg/dL