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Deamidated Gliadin IgA

CPT/HCPCS 86258
Order Code CH829
Turnaround Time 48-72 hrs
Specimen Requirements
Specimen Source
Serum
Transport Container
(Specimen Container)

Transport Tube

Preferred Specimens
1 mL Serum
Minimum Volume (uL)
0.5 mL
Collection Instructions
(Transport Temperature)
Room Temperature
Specimen Stability
Temperature Period
Room temperature 7 days
Refrigerated 14 days
Frozen 30 days
Reject Criteria

Gross hemolysis, Grossly lipemic

Test Details
Methodology
Immunoassay
Clinical Significance

Gliadin (Deamidated) Antibody (IgA) – Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.

Reference Ranges

=15.0 U/mL Antibody Detected