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Apolipoprotein A and B

CPT/HCPCS 82172x2
Order Code CH368
Turnaround Time 24 hours
Test Includes

Apolipoprotein A and Apolipoprotein B

Specimen Requirements
Specimen Source
Transport Container
(Specimen Container)

SST (Tiger Top)

Preferred Specimens
Minimum Volume (uL)
0.5 mL
Collection Instructions
(Transport Temperature)
Transport Refrigerated (cold packs)
Specimen Stability
Temperature Period
Room temperature 72 hours
Refrigerated 72 hours
Frozen 3 months at -20°C, 6 months at -70°C
Test Details
Clinical Significance

Apolipoprotein A1 (ApoA1) is the primary protein associated with high-density lipoprotein (HDL) particles, and plays a central role in reverse cholesterol transport.(1) HDL cholesterol (HDL-C) and ApoA1 concentrations are inversely related to the risk for coronary artery disease (CAD).(2) There are a variable number of ApoA1 proteins per HDL particle. Therefore, ApoA1 is not a 1:1 surrogate marker for HDL particles. Similarly, the number of ApoA1 proteins and the amount of cholesterol contained in HDL particles is highly variable. This heterogeneity has led to unique clinical findings related to ApoA1 compared with HDL-C. Apolipoprotein B (APO B) has been reported to be a powerful indicator of CAD. In some patients with CAD, APO B is elevated even in the presence of normal LDL cholesterol.

Reference Ranges

ApoA: Male >115,
Female >125 ApoB: <90