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Antiproteinase 3 (PR3) Abs

Order Code CH279
Turnaround Time 48-72 hrs
Specimen Requirements
Specimen Source
Transport Container
(Specimen Container)

Transport Tube

Preferred Specimens
1 mL Serum
Minimum Volume (uL)
0.3 mL
Collection Instructions
(Transport Temperature)
Room Temperature
Specimen Stability
Temperature Period
Room temperature 7 days
Refrigerated 14 days
Frozen 30 days
Reject Criteria

Gross hemolysis

Test Details
Clinical Significance

Autoimmune vasculitis diseases are characterized by abnormal immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown.

ANCA-associated vasculitis diseases are often characterized by the size of the blood vessels involved. The diseases present with diverse clinical features and are often rapidly progressive, causing irreversible injury to the vessels of the organs affected, such as the kidneys and lungs.

Goodpasture’s Syndrome, first described by Ernest Goodpasture in 1919, is characterized today by the triad of diffuse lung hemorrhage, proliferative nephritis and the presence of anti-GBM autoantibodies, which are present as linear deposits along the glomerular and alveolar basement membranes, and as circulating antibodies.

Reference Ranges

<1.0 AI No antibody detected >1.0 AI Antibody detected